Each kit is enough for 4 fl oz of cream or lotion at approximately 0.00005% concentration (50 mcg in 120 mL cream). Use in your favorite cream or add to our Canvas Base Cream or a Sea Kelp Bioferment base.

Mix thoroughly, but gently. Vigorous mixing will decrease the activity level of the EGF.

EGF is kept highly concentrated to preserve its activity, therefor you will hardly see the EGF drop at the bottom of the small tube. Store the EGF in the refrigerator until you are ready to use it. When ready to use, add the contents of the second tube (saline solution) to the tube containing EGF and close. Mix by inverting and straightening the tube several times. The EGF is now ready for addition to your cream, lotion, or serum. Do not be tempted to use it more concentrated than recommended. A growth factor is similar to a hormone: very little (it is measured in micrograms, one millionth of a gram) will go a very long way.

In 1986, Stanley Cohen received the Nobel Prize for his work elucidating the role of the Epidermal Growth Factor (EGF) in the regulation of cell growth and development. EGF is a growth factor that plays an important role in the regulation of cell growth, cell proliferation and differentiation. As with all growth factors, it is a small protein. EGF acts by binding to specific receptors on the cell surface, starting a cascade of very organized molecular events, including increased intracellular calcium concentration, energy production and protein synthesis. 

This is one the specialty proteins made by Skin Actives Scientific using biotechnology. Biotechnology is a short name for an array of sophisticated methods that allow scientists to make large amounts of a single protein, nearly pure and fully active, at a fraction of the cost of extracting it from the original source material. Please note that our growth factors are sold for use in cosmetics only.

Please ask us about wholesale pricing as well as custom protein development.

What is a growth factor? Growth factors, a.k.a. citokines, are naturally occuring proteins capable of stimulating cellular proliferation and cellular differentiation. Growth factors bind to specific receptors on the cell surfaces and are important for the regulation a variety of cellular processes. Among the practical uses of EGF are its use in accelerating healing of skin and cornea. EGF was the first growth factor to be discovered and studied, but many more factors have been found since then. These growth factors differ in size and structure, affecting different receptors and types of cells as a consequence, and causing various effects on the target cells.

Active ingredient in ReVive™ line.

Franklin J D; Lynch J B (1979) Plastic and reconstructive surgery.  Effects of topical applications of epidermal growth factor on wound healing. Experimental study on rabbit ears, 64(6), 766-70.

Mustoe, Thomas A.; Pierce, Glenn F.; Morishima, Chihiro; Deuel, Thomas F. (1991) Growth factor-induced acceleration of tissue repair through direct and inductive activities in a rabbit dermal ulcer model. Journal of Clinical Investigation , 87(2), 694-703.

Ricotti, G.; Tappa, M. M.; Tucci, M. G.; Pugnaloni, A.; Lucarini, G.; Biagini, G.; Bertani, A.; Toschi, E.; Castaldini, C. (1993) Tissue expansion improvement: the role of epidermal growth factor. Clin. Dermatol., Journal of Materials Science: Materials in Medicine, 4: 345-52.

Grahn, Jennifer C.; Isseroff, R. Rivkah. (2004) Human melanocytes do not express EGF receptors. Journal of Investigative Dermatology, 123: 244-246.

Mimura, Yoshihiro; Ihn, Hironobu; Jinnin, Masatoshi; Asano, Yoshihide; Yamane, Kenichi; Tamaki, Kunihiko (2004) Epidermal growth factor induces fibronectin expression in human dermal fibroblasts via protein kinase C d signaling pathway. Journal of Investigative Dermatology, 122: 1390-1398.

http://en.wikipedia.org/wiki/Epidermal_growth_factor