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Thioredoxin (TRX)



SKU 194

Quantity Price
10+ Items $11.25

Thioredoxins are proteins that act as antioxidants.

Skin Actives uses many valuable antioxidant chemicals that can be purified from plants, e.g. astaxanthin, alpha-D-tocopherol, and resveratrol, but they cannot replace the need for antioxidant enzymes, which are proteins.

Store the TRX in the refrigerator until you are ready to use it. When ready to use, add the contents of the tube with the clear cap (saline solution) to the tube with the green cap (TRX solution) and put the lid back on. Mix by inverting and straightening the tube several times. Make sure the solution is mixed thoroughly, but gently. Vigorous mixing will decrease the activity of the TRX.

Each kit is enough for 4 fl oz of cream or lotion at approximately 0.00005% concentration (50 mcg in 120 mL cream). Use in your favorite cream or add to our Canvas Base Cream or a Sea Kelp Coral.

Thioredoxin suspended in ammonium sulphate/water solution.

Thioredoxins are proteins that act as antioxidants by facilitating the reduction of other proteins by cysteine thiol-disulfide exchange. Thioredoxins are found in nearly all known organisms and are essential for life in mammals.

This is an enzyme I became familiar with in my days as a plant biochemist, long before Wikipedia (or the internet, for that matter) was invented. Thioredoxin is everywhere, including the regulation of the most abundant protein on earth, Rubisco (the enzyme that "fixes" carbon dioxide making life possible for every plant and animal, including us).

Thioredoxin will make sure that the chain of events keeping proteins in their "right" reduction state is kept well oiled. Or, in other words, thioredoxin will facilitate the reduction of your skin proteins by cysteine (in a disulfide bond|thiol-disulfide exchange). The Trx (thioredoxin) and Grx (glutaredoxin) systems control cellular redox potential, keeping a reducing thiol-rich intracellular state, which no generation of reactive oxygen species signals through thiol redox control mechanisms. 

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