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Polypodium Leucotomos Extract (PLE)



SKU 176

Quantity Price
10+ Items $5.85

We strongly recommend the use of this active for psoriasis, preferably in our Sea Kelp Coral as a base. Polypodium Leucotomos Extract (PLE) has also been shown to reduce the effects of UV damage.

Each tube is enough for 4 fl oz of cream or lotion at approximately 5% concentration (5 g in 120 mL cream). Use in your favorite cream or add to our Canvas Base Cream.

Adding Polypodium Leucotomos Extract to cream will turn it brown and give it a pleasant smell. When PLE is mixed with Sea Kelp, a brown gel forms.

Polypodium Leucotomos extract.

Polypodium is a fern, a relatively primitive plant that represents a bridge between green algae and higher plants. This evolutionary position means that some of the biochemicals found in Polypodium are very different from what you would find in flowering plants (although others, like rutin and kaempferol are also present in both PLE and many higher plants).

Polypodium is a genus of between 75-100 species of true ferns, widely distributed throughout the world, with the highest species diversity in the tropics. Polypodium leucotomos (a.k.a. Phlebodium decumanum) grows in Ecuador and Honduras.

Study of the many biochemicals present in this fern is a time-consuming process and we don’t know yet which components are responsible for the medicinal properties of PLE. However, calagualine (a saponin) has been mentioned as being responsible for the inhibition of tumor necrosis factor (TNF)-induced activation of nuclear transcription factor-B, thus blocking tumor metastasis, proliferation, and inflammation.

Psoriasis is one of the many diseases caused by the immune system, which should defend us from bacteria, viruses, and other external agents, but sometimes goes haywire. PLE may suppress psoriasis by inhibiting the production of inflammatory cytokines. PLE also protects from the effects of UVA radiation when taken orally or applied topically, and inhibits inflammation caused by long exposure to UVB radiation. So even for those who don’t have to worry about skin immune problems, PLE may help in preventing photoaging by improving membrane integrity, inhibiting metalloproteinases, and reversing the loss of normal elastic fibers associated with skin aging.

As more scientists and doctors learn of the multiple actions of PLE, it is tested on more diseases that involve disruption of the immune system or the inflammatory process, such as atopic dermatitis and vitiligo.

Alonso-Lebrero, Jose Luis; Dominguez-Jimenez, Carmen; Tejedor, Reyes; Brieva, Aurora; Pivel, Juan Pablo. (2003) Photoprotective properties of a hydrophilic extract of the fern Polypodium leucotomos on human skin cells. Journal of Photochemistry and Photobiology, B: Biology,70:31-37. Gonzalez S, Alcaraz MV, Cuevas J, Perez M, Jaen P, Alvarez-Mon M, Villarrubia VG. (2,000) An extract of the fern Polypodium leucotomos (Difur) modulates Th1/Th2 cytokines balance in vitro and appears to exhibit anti-angiogenic activities in vivo: pathogenic relationships and therapeutic implications. Anticancer Res. 20:1567-75.

Gonzalez S; Pathak M A; Cuevas J; Villarrubia V G; Fitzpatrick T B (1997) Topical or oral administration with an extract of Polypodium leucotomos prevents acute sunburn and psoralen-induced phototoxic reactions as well as depletion of Langerhans cells in human skin. Photodermatology, photoimmunology & photomedicine, 13: 50-60.

Jimenez D; Naranjo R; Doblare E; Munoz C; Vargas J F Anapsos (Polypodium leucotomos extract), an antipsoriatic drug, in atopic dermatitis. (1987) Allergologia et immunopathologia, 15: 185-9.

Manna SK, Bueso-Ramos C, Alvarado F, Aggarwal BB (2003) Calagualine inhibits nuclear transcription factors-kappaB activated by various inflammatory and tumor promoting agents. Cancer Lett.,20:171-82.

Philips, Neena; Smith, Joan; Keller, Thomas; Gonzalez, Salvador. (2003) Predominant effects of Polypodium leucotomos on membrane integrity, lipid peroxidation, and expression of elastin and matrixmetalloproteinase-1 in ultraviolet radiation exposed fibroblasts, and keratinocytes Journal of Dermatological Science, 32:1-9.

Pineiro Alvarez B (1983) 2 years personal experience in anapsos treatment of psoriasis in various clinical forms. Medicina cutanea ibero-latino-americana, 11: 65-72.

Sempere, J. M.; Rodrigo, C.; Campos, A.; Villalba, J. F.; Diaz, J. (1997) Effect of Anapsos (Polypodium leucotomos extract) on in vitro production of cytokines. British Journal of Clinical Pharmacology, 43: 85-89.

Customer Reviews**

  • Author: Barbara Bogosian
    I tried the PLE extract and it was horrible. It did not dissolve. It was like putting sand into the sea kelp bioferment. I ended up throwing it away, so I lost two ounces of bioferment and this stuff. So I thre away twenty dollars.
  • Author: Jean Stearns
    This mixes well with Burt's Bees After Sun Soothing Cream, which is mainly aloe vera, glycerine and linden and has a lotion like texture. You have to empty the tube into a bowl, stir well, let sit a bit and then put in a jar. It's very slightly grainy when you put it on but soon soaks in anyway. It feels terrific. Just one of the few things that leaves my hypersensitive skin feeling good for hours. I use it as my moisturizer, over baby sunscreen. Hope you'll keep carrying it!


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