Product Catalog / Polypodium Leucotomos Extract (PLE)
Polypodium Leucotomos Extract (PLE)

Polypodium Leucotomos Powder Detail
Polypodium Leucotomos Extract (PLE)
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Size: 5 Grams

Price: $6.50      In Stock
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Body Part Body     Face     Hair    
Skin Type Combination     Dry Skin     Normal Skin     Oily Skin    
Sex Male     Female    
Age Adolescent     20s/30s     40s/50s     60+    
Solubility Recipe Cream    
Product Style Do It Yourself    
Need/Issue Antioxidant Rich     Cancer Prevention     Eczema     Hyperpigmentation     Inflammation     Prevent Oxidative Damage     Psoriasis     Sun Damage    
Ingredient Type Botanical Extract (Powder)     Powder    

We strongly recommend the use of this active for psoriasis, preferably in the seakelp gel. PLE has also been shown to reduce the effects of UV damage.

Polypodium is a fern, a relatively primitive plant that represents a bridge between green algae and higher plants. This evolutionary position means that some of the biochemicals found in Polypodium are very different from what you would find in flowering plants (although others, like rutin and kaempferol are also present in both PLE and many higher plants).

Polypodium is a genus of between 75-100 species of true ferns, widely distributed throughout the world, with the highest species diversity in the tropics. Polypodium leucotomos (a.k.a. Phlebodium decumanum) grows in Ecuador and Honduras.

Study of the many biochemicals present in this fern is a time-consuming process and we don’t know yet which components are responsible for the medicinal properties of PLE, although calagualine, a saponin, have been mentioned as responsible for the inhibition of tumor necrosis factor (TNF)-induced activation of nuclear transcription factor-B, thus blocking tumor metastasis, proliferation, and inflammation.

Psoriasis is one of the many diseases caused by the immune system, which should defend us from bacteria, viruses and other external agents, but sometimes goes haywire. PLE may suppress psoriasis by inhibiting the production of inflammatory cytokines. PLE also protects from the effects of UVA radiation when taken orally or applied topically, and inhibits inflammation caused by long exposure to UVB radiation, so even for those who don’t have to worry about skin immune problems, PLE may help and in preventing photoaging by improving membrane integrity, inhibiting metalloproteinases and reversing the loss of normal elastic fibers associated with skin aging.

As more scientists and doctors learn of the multiple actions of PLE, it is tested on more diseases that involve disruption of the immune system or the inflammatory process, like atopic dermatitis and vitiligo.

The administration of oral P leucotomos to a group of high-risk patients with malignant melanoma or atypical mole syndrome led to a significant reduction in sensitivity to UVR in all patients.92 Other studies have found that oral administration of 480 to 1200 mg daily of this well tolerated extract can prevent polymorphous light eruption lesions in patients with polymorphous light eruption. 93 and 94P leucotomos has been shown to reduce the known effects of UVR, including minimal erythema dose, minimal phototoxic dose, UV-induced epidermal proliferation, development of DNA damage and isomerization, decomposition of trans-UCA, and the generation of ROS. 95 and 96


In short, PLE is a beautiful “package” that can improve the lives of many people. We at SAS are very proud to be able to offer you such a great active.

Each tube is enough for 4 fl oz of cream or lotion at approximately 5% concentration (5 g in 120 mL cream). Use in your favorite cream or add to our Canvas Base Cream or a Sea Kelp Bioferment base. The resulting cream is brown with a pleasant smell and will absorb rapidly into the skin. When mixed with Sea Kelp, a brown gel forms.

Pineiro Alvarez B (1983) 2 years personal experience in anapsos treatment of psoriasis in various clinical forms. Medicina cutanea ibero-latino-americana, 11: 65-72.

Philips, Neena; Smith, Joan; Keller, Thomas; Gonzalez, Salvador. (2003) Predominant effects of Polypodium leucotomos on membrane integrity, lipid peroxidation, and expression of elastin and matrixmetalloproteinase-1 in ultraviolet radiation exposed fibroblasts, and keratinocytes Journal of Dermatological Science, 32:1-9.

Alonso-Lebrero, Jose Luis; Dominguez-Jimenez, Carmen; Tejedor, Reyes; Brieva, Aurora; Pivel, Juan Pablo. (2003) Photoprotective properties of a hydrophilic extract of the fern Polypodium leucotomos on human skin cells. Journal of Photochemistry and Photobiology, B: Biology,70:31-37. Gonzalez S, Alcaraz MV, Cuevas J, Perez M, Jaen P, Alvarez-Mon M, Villarrubia VG. (2,000) An extract of the fern Polypodium leucotomos (Difur) modulates Th1/Th2 cytokines balance in vitro and appears to exhibit anti-angiogenic activities in vivo: pathogenic relationships and therapeutic implications. Anticancer Res. 20:1567-75.

Manna SK, Bueso-Ramos C, Alvarado F, Aggarwal BB (2003) Calagualine inhibits nuclear transcription factors-kappaB activated by various inflammatory and tumor promoting agents. Cancer Lett.,20:171-82.

Gonzalez S; Pathak M A; Cuevas J; Villarrubia V G; Fitzpatrick T B (1997) Topical or oral administration with an extract of Polypodium leucotomos prevents acute sunburn and psoralen-induced phototoxic reactions as well as depletion of Langerhans cells in human skin. Photodermatology, photoimmunology & photomedicine, 13: 50-60.

Jimenez D; Naranjo R; Doblare E; Munoz C; Vargas J F Anapsos (Polypodium leucotomos extract), an antipsoriatic drug, in atopic dermatitis. (1987) Allergologia et immunopathologia, 15: 185-9.

Sempere, J. M.; Rodrigo, C.; Campos, A.; Villalba, J. F.; Diaz, J. (1997) Effect of Anapsos (Polypodium leucotomos extract) on in vitro production of cytokines. British Journal of Clinical Pharmacology, 43: 85-89.

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Customer Reviews

  • Author: Barbara Bogosian
    I tried the PLE extract and it was horrible. It did not dissolve. It was like putting sand into the sea kelp bioferment. I ended up throwing it away, so I lost two ounces of bioferment and this stuff. So I thre away twenty dollars.
  • Author: Jean Stearns
    This mixes well with Burt's Bees After Sun Soothing Cream, which is mainly aloe vera, glycerine and linden and has a lotion like texture. You have to empty the tube into a bowl, stir well, let sit a bit and then put in a jar. It's very slightly grainy when you put it on but soon soaks in anyway. It feels terrific. Just one of the few things that leaves my hypersensitive skin feeling good for hours. I use it as my moisturizer, over baby sunscreen. Hope you'll keep carrying it!