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Polypodium Leucotomos Extract (PLE)

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SKU 176

Quantity Price
10-24 Items $4.25
25+ Items $4.00

Skin Concern: Redness and irritation, dryness

Skin Type:

Dr. Sivak's Notes:

• PLE has anti-irritation activity and helps with chapped, red skin.

• This powerful antioxidant reduces free radicals formed by the sun, pollution, and heat.

Polypodium is a fern, a relatively primitive plant that represents a bridge between green algae and higher plants.

• Find this in our ready made Olive Anti-Inflammatory Cream.


Purchase 10 or more for an automatic discount. Other sizes available upon request at


Cream Soluble Only    
Anti-Aging     Healthy Skin     Redness & Irritation    
Paraben Free Actives    
Animal Free Actives    
Product Style Do It Yourself    

Each tube is enough for 4 fl oz of cream or lotion at approximately 5% concentration (5 g in 120 mL cream). Use in your favorite cream or add to our Canvas Base Cream.

Adding Polypodium Leucotomos Extract to cream will turn it brown and give it a pleasant smell. 

Polypodium Leucotomos Leaf Extract

Polypodium is a fern, a relatively primitive plant that represents a bridge between green algae and higher plants. This evolutionary position means that some of the biochemicals found in Polypodium are very different from what you would find in flowering plants. Others, like rutin and kaempferol are also present in both PLE and many higher plants.*


Polypodium is a genus of between 75-100 species of true ferns, widely distributed throughout the world, with the highest species diversity in the tropics. Polypodium leucotomos (a.k.a. Phlebodium decumanum) grows in Ecuador and Honduras.*


Psoriasis is one of the many diseases caused by the immune system, which should defend us from bacteria, viruses, and other external agents, but sometimes goes haywire. PLE may suppress psoriasis by inhibiting the production of inflammatory cytokines. PLE also protects from the effects of UVA radiation when taken orally or applied topically, and inhibits inflammation caused by long exposure to UVB radiation. So for those who don’t have to worry about skin immune problems, PLE may help in preventing photoaging by improving membrane integrity, inhibiting metalloproteinases, and reversing the loss of normal elastic fibers associated with skin aging.*


As more scientists and doctors learn of the multiple actions of PLE, it is tested on more diseases that involve disruption of the immune system or the inflammatory process, such as atopic dermatitis and vitiligo.*


(*See reference tab for scientific resources)


Alonso-Lebrero, Jose Luis; Dominguez-Jimenez, Carmen; Tejedor, Reyes; Brieva, Aurora; Pivel, Juan Pablo. (2003) Photoprotective properties of a hydrophilic extract of the fern Polypodium leucotomos on human skin cells. Journal of Photochemistry and Photobiology, B: Biology,70:31-37. Gonzalez S, Alcaraz MV, Cuevas J, Perez M, Jaen P, Alvarez-Mon M, Villarrubia VG. (2,000) An extract of the fern Polypodium leucotomos (Difur) modulates Th1/Th2 cytokines balance in vitro and appears to exhibit anti-angiogenic activities in vivo: pathogenic relationships and therapeutic implications. Anticancer Res. 20:1567-75.

Gonzalez S; Pathak M A; Cuevas J; Villarrubia V G; Fitzpatrick T B (1997) Topical or oral administration with an extract of Polypodium leucotomos prevents acute sunburn and psoralen-induced phototoxic reactions as well as depletion of Langerhans cells in human skin. Photodermatology, photoimmunology & photomedicine, 13: 50-60.

Jimenez D; Naranjo R; Doblare E; Munoz C; Vargas J F Anapsos (Polypodium leucotomos extract), an antipsoriatic drug, in atopic dermatitis. (1987) Allergologia et immunopathologia, 15: 185-9.

Manna SK, Bueso-Ramos C, Alvarado F, Aggarwal BB (2003) Calagualine inhibits nuclear transcription factors-kappaB activated by various inflammatory and tumor promoting agents. Cancer Lett.,20:171-82.

Philips, Neena; Smith, Joan; Keller, Thomas; Gonzalez, Salvador. (2003) Predominant effects of Polypodium leucotomos on membrane integrity, lipid peroxidation, and expression of elastin and matrixmetalloproteinase-1 in ultraviolet radiation exposed fibroblasts, and keratinocytes Journal of Dermatological Science, 32:1-9.

Pineiro Alvarez B (1983) 2 years personal experience in anapsos treatment of psoriasis in various clinical forms. Medicina cutanea ibero-latino-americana, 11: 65-72.

Sempere, J. M.; Rodrigo, C.; Campos, A.; Villalba, J. F.; Diaz, J. (1997) Effect of Anapsos (Polypodium leucotomos extract) on in vitro production of cytokines. British Journal of Clinical Pharmacology, 43: 85-89.

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Customer Reviews**

  • Author: Jean Stearns
    This mixes well with Burt's Bees After Sun Soothing Cream, which is mainly aloe vera, glycerine and linden and has a lotion like texture. You have to empty the tube into a bowl, stir well, let sit a bit and then put in a jar. It's very slightly grainy when you put it on but soon soaks in anyway. It feels terrific. Just one of the few things that leaves my hypersensitive skin feeling good for hours. I use it as my moisturizer, over baby sunscreen. Hope you'll keep carrying it!


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