Each tube is enough for 32 fl oz of cream or lotion at approximately 0.5% concentration (5 g in 960 mL cream) or approximately 5% when the whole tube is added to 4 oz cream or gel. Use in your favorite cream or add to our Canvas Base Cream or our Sea Kelp Coral.
Warning: Please note that application of niacinamide is contraindicated for people affected by Parkinson's disease.
The biochemical effects of Niacinamide include increased concentration of NADPH (the donor of reducing power in cell biosynthesis), an effect that translates into increased synthesis of collagen, involucrin, filaggrin, and keratin.*
This molecule is one of the components of NADPH (reduced niacinamide adenine dinucleotide phosphate), the coenzyme that provides the reducing power required to build new molecules in the human body. Niacinamide and niacin are not synthesized in the human body and, therefore, must be supplied externally (this is why we call niacin a vitamin) either through the diet or through topical application.*
Niacinamide is also part of NAD (like NADP but without the extra phosphate), the molecule that is found wherever carbohydrates and other foodstuffs are oxidized (respired) to make energy. Even when following a normal healthy diet, topical application of niacinamide will result in increased synthesis of collagen, keratin, involucrin, and filaggrin. Topical application of niacinamide will decrease pruritus and inflammation, help acne affected skin, decrease oiliness, alleviate atopic dermatitis and help decrease facial pigmentation. These are just a few of the beneficial effects of topical application of niacinamide to the skin, and it would be suspicious that there are so many were it not for the crucial role of this chemical in human metabolism.*
(*See reference tab for scientific resources)
Bissett, Donald L.; Oblong, John E.; Berge, Cynthia A. Niacinamide: a B vitamin that improves aging facial skin appearance Dermatologic Surgery (2005), 31: 860-865.
Namazi, Mohammad R. Nicotinamide in dermatology : a capsule summary. International Journal of Dermatology (2007), 46: 1229-1231.