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Keratinocyte Growth Factor (KGF)

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$12.50

Size

SKU 146

Quantity Price
10-24 Items $10.63
25+ Items $10.00
*Note:

Skin Concern: Healthy hair

Skin Type: All skin types

Dr. Sivak's Notes:

This protein is a member of the fibroblast growth factor family and has been found to promote healthy hair.

KGF is available in our ready-to-use Hair Care Serum and Brow and Lash Serum.

Data sheet for KGF HERE.

 

Purchase 10 or more for an automatic discount. Other sizes available upon request at care@skinactives.com.

 

 

Peptide Actives    
Animal Free Actives    
Paraben Free Actives    
Product Style Do It Yourself    
Water & Cream Soluble    
Healthy Hair     Specialty    

KGF is kept highly concentrated to preserve its activity, therefore you will hardly see the KGF drop at the bottom of the small tube.

Store the KGF in the refrigerator until you are ready to use it. When ready to use, add the contents of the tube with the clear cap (saline solution) to the tube with the yellow cap (KGF solution) and put the lid back on. Mix by inverting and straightening the tube several times. Make sure the solution is mixed thoroughly, but gently. Vigorous mixing will decrease the activity of the KGF protein.

The KGF is now ready for addition to your cream, lotion, serum, leave-in conditioner, or other leave-on product. Do not be tempted to use it more concentrated than recommended. A growth factor is similar to a hormone: very little (it is measured in micrograms, one millionth of a gram) will go a very long way.

Each kit is enough for 4 fl oz of cream, lotion, or serum at approximately 0.00005% concentration (50 mcg in 120 mL cream). Use in your favorite cream or add to our Canvas Base Cream or our Sea Kelp Coral.

sh-Polypeptide-3 suspended in ammonium sulphate/water solution.

 

Keratinocyte Growth Factor (KGF) binds to the KGF receptor on the cell surface, acting as both a growth and survival factor by stimulating epithelial cell proliferation, differentiation, and migration, and promoting a number of cell protective mechanisms. KGF is also known as FGF-7 and heparin-binding growth factor-7 (HBGF-7). KGF is a member of the fibroblast growth factor family and has been found to stimulate hair growth. Cells that respond to KGF do so because they have receptors on the cell membrane that recognize the growth factor, normally produced by cells near or far from the target cell. The binding of the Growth Factor to the receptor initiates a cascade of molecular events that will eventually lead, among other effects, to cell division. Keratinocyte growth factor has been shown to regulate proliferation and differentiation in epithelial tissues, and may regulate the stem cells of the hair follicle.*

 

(*See reference tab for scientific resources)

 

Data sheet for KGF HERE.

 

Beer, HD, Bittner, M, Niklaus, G, Munding, C, Max, N); Goppelt, A, Werner, S (2005) The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair. Oncogene, 24: 5269-5277

Braun, Susanne, Krampert, Monika, Bodo, Enikoe, Kuemin, Angelika, Born-Berclaz, Christiane, Paus, Ralf, Werner, Sabine. (2006) Keratinocyte growth factor protects epidermis and hair follicles from cell death induced by UV irradiation, chemotherapeutic or cytotoxic agents Journal Cell Science, 119: 4841-4849

Danilenko, Dimitry M.; Ring, Brian D.; Yanagihara, Donna; Benson, William; Wiemann, Bernadette; Starnes, Charles O.; Pierce, Glenn F. (1995) Keratinocyte growth factor is an important endogenous mediator of hair follicle growth , development, and differentiation. Normalization of the nu/nu follicular differentiation defect and amelioration of chemotherapy induced alopecia. American Journal of Pathology 147: 145-54.

Guo, Lifei; Degenstein, Linda; Fuchs, Elaine (1996) Keratinocyte growth factor is required for hair development but not for wound healing. Genes & Development 10:165-75.

Jang, JH (2005) Stimulation of human hair growth by the recombinant human keratinocyte growth factor-2 (KGF-2). Biotechnology Letters, 27:749-52.

Karvinen, S; Pasonen-Seppanen, S; Hyttinen, JMT; Pienimaki, JP; Torronen, K, Jokela, TA; Tammi, MI, Tammi, R (2003) Keratinocyte growth factor stimulates migration and hyaluronan synthesis in the epidermis by activation of keratinocyte hyaluronan synthases 2 and 3. J Biol Chem, 278:49495-49504.

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Customer Reviews**

  • Author: Erin
    It has been over a month since I began using this for my eyelashes. I saw growth after 2 weeks. My lashes are not necessarily longer than they were before but I find it helps me from losing lashes. Since I hit 39-40 my lashes were falling out when I curled them. So this is an affordable solution! Erin
  • Author: Julia D
    I originally bought this to help my skimpy eyelashes, and to help thicken my hair by reducing shedding. I can honestly say that after about 3 or 4 weeks, I noticed that my eyelashes were hitting the lenses on my glasses - something that never happened before. I also noticed that my hair immediately shed less in the shower - down from a disturbing clump to 1, 2 or none per shower. I also noticed that using mascara now made more of a difference, whereas before using this product, mascara didn't help much (and I kept using the same mascara brand.) Lastly, when I started seeing my husband, I turned him onto this product, since he was concerned about a thinning patch on the crown of his head. (I also suggested he take biotin supplement, which he did, and still does.) He immediately noticed he shed less hair in the shower, and I noticed the patch slowly filling-in, and is barely noticeable now at all. In fact, his whole head of hair looks much thicker and healthier - he has baby fine hair to begin with. We are both 53. I'm a VERY skeptical person, but I have watched this product work as promised on both myself and my husband. I highly recommend it to anyone who wants to improve their lashes or hair. :)
  • Author: LC
    I love this! I have long had this one completely bald spot that refused to grow no matter what I did. Very distressing for a a woman in her early 30s. I had tried this before in some liquid based applications with very little success. I finally incorporated it into a cream with micro circulation stimulators (ginseng, ginger and gingko biloba) and not even a month later I have peach fuzz in that spot!
  • Author: Matthewwek
    Sleep apnea has long disrupted the lives of untold number of sufferers as well as their loved ones. To stand a good chance of effectively manage this difficult condition, solid knowledge and understanding of its causes is necessary. Apply the information in this piece, and you will possess the information needed to mitigate the impact sleep apnea has on your life.

    To help with your sleep apnea, you need to consult with your doctor about the best CPAP machine to use. Take into consideration both the noise and size of the CPAP machine. Some machines are smaller than a bread box and can be whisper quiet. Your doctor should be able to point you in the right direction of a capable machine.

    If you have just been diagnosed with sleep apnea and prescribed a CPAP, join a CPAP support group. It can be quite difficult to get used to sleeping with a mask on your face every night. Sitting in a room full of other people going through the same thing can be very empowering. You can learn from others who have had the same issues you are having and made adjustments to make it work.

    If you suffer from sleep apnea and you use a CPAP, carry your medical ID. If you need medical attention, it's vital that the people treating you know about your condition and that you use a CPAP machine. Your ID should tell people about your sleep apnea, your use of a CPAP, and the proper pressure level for it.

    Sleeping at a high altitude can worsen your sleep apnea because of the lower levels of oxygen. If you are going to a place located higher than what you are used to, take a CPAP machine with you. The best thing to do would be to completely avoid high altitude.

    Clear up your nasal passage before heading to bed. If you suffer from sleep apnea and have problems with a "stuffed up" nose, using a nasal spray or device can help clear your nasal airway. This is not a permanent solution, but one you can use when your apnea symptoms are the worst.

    An excellent way to help lessen the effects of sleep apnea is by losing weight. Sometimes, losing weight is all it takes to get rid of sleep apnea. Even a nominal amount of weight loss will go a long way in improving your breathing at night.

    You can reduce sleep apnea with exercises to strengthen throat muscles. Sleep apnea is often caused by the tissues in the throat, which can relax and collapse while you sleep. When your muscles strengthen, their chances of collapse and airway blockage go down.

    If simple changes in your lifestyle, such as regular sleep hours and losing weight, have not eliminated your sleep apnea episodes, it is time to consult with a sleep specialist. The specific causes of your sleep apnea can be evaluated, and an individual treatment plan can be designed for you.

    There are several things that can trigger sleep apnea and there are many treatments. Since you have read this article, you have increased your knowledge about dealing with your sleep apnea. Pass this knowledge on to others whose lives may be affected by this condition. A great night of sleep is still very possible for you.

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