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Gray Hair Serum



SKU 49

Quantity Price
10+ Items $20.25

Skin Concern: Healthy hair

Skin Type: All skin types

Dr. Sivak's Notes:

The objective of our Gray Hair Serum is to try to prevent the loss of hair color using catalase, methionine sulfoxide reductase, phloretin and L-methionine among other antioxidant actives.

The non-oxidant environment provided by our serum may prevent further loss of color.

Shake gently before each use. Gently massage serum into damp scalp once daily after a bath or shower and leave on, ideally overnight.

If you can’t leave on overnight, please allow at least two hours before rinsing serum from scalp.

Distilled water, sea kelp bioferment, L-acetyl carnitine, niacinamide, coconut endosperm, dithiothreitol, chrysin, L-methionine, L-arginine, L-glutamine, D-glucose, phloretin, catalase, methionine sulfoxide reductase, propylene glycol, diazolidinyl urea, methylparaben (and) propylparaben.

Oxygen, now 21% of the air, is a relatively newcomer to the atmosphere that started accumulating with the development of photosynthesis a few billions of years ago. Respiration, which uses oxygen as the final electron acceptor, is a process that oxidizes organic matter through a series of complex electron transports, extracting most of the energy stored in sugars, amino acids, etc. Increased oxygen concentration in the atmosphere made possible the huge increase in energy extraction provided by respiration, and is a great advantage to life forms that can use oxygen. However, it also brings disadvantages.*


Reactive oxygen species (ROS) are free radicals that contain the oxygen atom, are highly reactive, and can be very destructive. ROS are formed as a byproduct of respiration and other life processes, and by external agents, like ultraviolet radiation. Living beings that survived the rise in oxygen concentration (from nothing to 21%) have evolved numerous antioxidant mechanisms to disarm ROS. Some antioxidants are obtained from the diet, like vitamin C, vitamin E, carotenoids, and polyphenols; and others are produced by our bodies, like glutathione and thioredoxin. Antioxidant enzymes, like superoxide dismutases and glutathione peroxidases, are also required.*


When ROS reach our scalp, there are enzymes ready to disarm them. When ROS bypass the defenses, they reach proteins and nucleic acids and cause damage. Some enzymes are capable of repairing such damage.*


Gray hair is what happens when endogenous antioxidant systems fail.*


Let’s talk about two antioxidant enzymes present in our scalp. One enzyme, catalase, protects us from ROS by disarming them. Another, methionine sulfoxide reductase (MSR), fixes damage to proteins after it occurs. Inadequacy of these two enzymes seems to be the key to why our hair turns gray.*


Catalase is the enzyme that breaks down hydrogen peroxide into less reactive oxygen and water molecules, preventing damage to the cell's DNA, proteins, and membrane lipids.*


2 H2O2 → 2 H2O + O2


Methionine sulfoxide reductase repairs protein damage caused by ROS that escape the first line of defense. In the scalp, MSR can fix a damaged amino acids in tyrosinase so that it can keep catalyzing the first key step in the synthesis of melanin.*


Gray hair is produced by hair follicles lacking in these two crucial antioxidant enzymes, and our Gray Hair Serum is offering these two enzymes that will help protect your scalp and prevent the loss of hair color.*

(*See reference tab for scientific resources)

Wood, J. M., Decker, H., Hartmann, H., Chavan, B., Rokos, H., Spencer, J. D., Hasse, S., Thornton, M. J., Shalbaf, M., Paus, R., Schallreuter, K. U. (2009) Senile hair graying: H2O2-mediated oxidative stress affects human hair color by blunting methioninesulfoxide repair. July 2009 The FASEB Journal vol. 23 no. 7 2065-2075. 

Customer Reviews**

  • Author: randy spina
    I started using this serum a few months ago after the grays were starting to come in, especially around my temples. After a few haircuts the grays are noticeably less. I am 55, do not color my hair at all and last week someone asked "why don't you have any gray hair"? I highly recommend this but don't expect overnight results, be patient and you will se a change.
  • Author: CH
    I've been using it on my beard for about 6 weeks. It does seem to be helping. A miracle as far as I'm concerned!
  • Author: Jillian
    This is an amazing product. I have been using this serum every morning for the past 4 months. One bottle usually lasts around 5 weeks. I have had white/silver hair for the past 7 years over most of my scalp with a little dark gray hair still remaining towards the back of my head. I now have dark hair growing around the front of my hair line, incredible,wonderful. The area that was remaining gray is now darkening and extending over the scalp towards the crown and side of head. I have just started using on my eyebrows as they were also starting to go white. Thank you to all those involved in the production of Gray Hair Serum this will make a major impact on the emotional well being of a lot of people
  • Author: Girleebleu
    I was curious about this but it didn't work well enough to stop dying my hair... But the worst part was the smell! It has a terrible odor, and my husband couldn't stand it either.
  • Author: Fiona R
    I have been using this serum for 5 years, maybe more, it has worked for me, I am 56 years old and had a few grey hairs when I started using it, but now have none, my younger sister and older brother are grey and my mum is white. I would recommend it to anybody. I don’t use it all the time just a couple of times a fortnight, and I leave it in. I also brought mum the hair serum because she was thinning on top she started using it in July, she stopped using it because the new hair that was going back was dark and she likes her white hair, but it worked!! At Christmas she had 2cm new growth all though her hair and yes some were a darker grey colour, so both serums work on our genes good luck with yours.


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