CALL US: +1 (480) 813 5633
USD ($)
United States
  • Select currency:
  • Select your country:

Grape Seed Proanthocyanidins

Sign in to rate



SKU 133

Quantity Price
10-24 Items $7.23
25+ Items $6.80

Skin Concern: Redness, irritation, oxidative stress

Skin Type: All skin types

Dr. Sivak's Notes:

Grape Seed Proanthocyanidins are a very potent antioxidant that help to reduce redness and irritation.

Provides protection against oxidative stress and helps support the synthesis of collagen.


Purchase 10 or more for an automatic discount. Other sizes available upon request at

Cream Soluble Only    
Paraben Free Actives    
Animal Free Actives    
Product Style Do It Yourself    
Healthy Skin     Redness & Irritation     Specialty    

Add a small quantity of the powder to a base cream, such as our Canvas Base Cream, and mix well. Add more powder and mix as desired, but stop when the cream is a color that you are happy with. Add the powder slowly because the active is strongly colored.

Vitis Vinifera (Grape) Seed Extract.

Grape seed extract is a great source of proanthocyanidins. Proanthocyanidins are flavonoids that protect capillary walls and inhibit the enzymes that break down collagen (collagenase), hyaluronic acid (hyaluronidase), and elastin (elastase). They are also anti-inflammatory, antihistaminic, antiallergenic, and act as major free radical scavengers.*


(*See reference tab for scientific resources)


Blazsó, G. Gábor, M. "Oedema-inhibiting effect of procyanidin." Acta Physiologica Academiae Scientiarum Hungaricae, Tomus (1980). 56(2) pp. 235-240.

Bouhamidi R, Prevost V, Nouvelot A. (1988) High protection by grape seed proanthocyanidins (GSPC) of polyunsaturated fatty acids against UV-C induced peroxidation. C R Acad Sci III, 321(1):31-8.

Fitzpatrick DF, Bing B, Rohdewald P. (1998) Endothelium-dependent vascular effects of Pycnogenol. J Cardiovasc Pharmacol., 32(4):509-15.

Garbacki, N.; Kinet, M.; Nusgens, B.; Desmecht, D.; Damas, J.(2005) Proanthocyanidins from Ribes nigrum leaves, reduce endothelial adhesion molecules ICAM-1 and VCAM-1. Journal of Inflammation (London, United Kingdom) 2:9

Packer L, Rimbach G, Virgili F. (1999) Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic Biol Med., 27(5-6):704-24.

Product rating

Sign in to rate

Customer Reviews**

There have been no reviews for this product.


Join the Skin Actives Monthly Newsletter!

* indicates required