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 | Body Eyebrows/Eyelashes Eyes Face Feet Hair Hands Lips | |
 | Combination Dry Skin Normal Skin Oily Skin | |
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 | Adolescent 20s/30s 40s/50s 60+ | |
 | Recipe Cream Recipe Liquid (Water) | |
 | Biotech Protein Skin Actives Exclusive Hi-Tech Suspension | |
 | Antioxidant Rich |
Product Catalog / Glutaredoxin (GRX)
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It took years of preparation but here it is: glutaredoxin! I know that it does not sound sexy, but maybe it will after you read the following (from the patent application):
“Methods for the prevention and treatment of skin damage arising from the exposure to UV radiation, air pollution and other stressors capable of leading to the formation of free radicals, using the small dithiol protein glutaredoxin in a dermatologically acceptable carrier that can be applied topically are disclosed. Some embodiments may include other proteins such as superoxide dismutase and/or catalase, as well as other antioxidant molecules such as reduced glutathione, vitamin E, vitamin C, lycopene, astaxanthin and/or tocotrienols.”
If you still don’t think it sounds sexy, maybe this will change your mind: think as big as vitamin C but an enzyme, like superoxide dismutase, but doing a job that neither ascorbic acid or superoxide dismutase can do.
“Glutaredoxin seems to provide antioxidant protection in human coronary arteries and placental function against the oxidative stress caused by pre-eclampsia and may even protect cerebellar granule neurons from dopamine-induced programmed cellular death. Glutaredoxin may also help catalyze the regeneration of ascorbic acid…”, so there you are!
This does not mean that using glutaredoxin will make you younger, but will certainly help keep your skin healthy.
Glutaredoxins are small redox enzymes of approximately one hundred amino-acid residues which use glutathione as a cofactor. Glutaredoxins are oxidized by substrates and reduced non-enzymatically by glutathione. In contrast to Thioredoxins, which are reduced by Thioredoxin reductase, no oxidoreduc¬tase exists that specifically reduces Glutaredoxins. Instead, Glutaredoxins are reduced by the oxidation of glutathione and reduced glutathione is then regenerated by glutathione reductase. Together these components form the glutathione system.
Like Thioredoxin, which functions in a similar way, Glutaredoxin possesses an active center disulfide bond. It exists in either a reduced or an oxidized form where the two cysteine residues are linked in an intramolecular disulfide bond. Glutaredoxins function as electron carriers in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. Moreover, Glutaredoxins act in antioxidant defence by reducing dehydroascorbate, peroxiredoxins and Methione Sulfoxide Reductase (also supplied by Skin Actives). Beside their function in antioxidant defense, bacterial and plant GRX were shown to bind iron-sulfur clusters and to deliver the cluster to enzymes on demand.
Contact Jonatan (jonatan@skinactives.com) for wholesale pricing.
Each Kit is enough for 4 oz of cream or lotion and can be combined with our other actives. Use in your favourite cream or purchase our Canvas base cream or Sea Kelp bioferment (sea kelp is perfect for people with oily skin).
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| Thioredoxin (TRX) | Bright-I Serum | Antioxidant Serum with Glutaredoxin and SOD (CHAS) | Coffee Antioxidant Cream |
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$12.50
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$17.50
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$13.25
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$28.00
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| Antioxidant Booster | Betulinic Acid | Coenzyme Q10 | Epidermal Growth Factor BT (EGF) |
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$17.50
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$13.50
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$9.50
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$9.50
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| Exfoliating Mask | M and A Booster Cream | Olive Extract in Squalane | Scale |
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$17.50
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$18.50
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$31.50
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$15.00
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| Serum Quartet Set | |||
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$45.00
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