Can we do better than Matrixyl 3000? Yes: palmitoyl tetrapeptide-3 and GHK-copper solution Peptides are strings of amino acids linked to each other. Amino acids are relatively small molecules, the smallest is glycine, with just two carbons, one the acid group (COO-) and the other with the amino group (NH4+) attached to it. There are many amino acids, but only 20
are common in proteins.

Please note that we recommend alternate products such as our natural active peptides and dermagen. This product is offered to those customers who wish to simulate the effect of matrixyl 3000.

Nomenclature refresher: dipeptide (two amino acids linked by a peptide bond), tripeptide (3), tetrapeptide (4), etc. For more than six (hexa) or seven (hepta) use the word oligopeptide (oligo= few). Peptides are usually represented by a sequence of letters, one for each amino acid, and sometimes by a sequence of three letters for each amino acid.

The skin care industry uses synthetic peptides that mimic peptides occurring naturally and modifies them by attaching a fatty acid to one end. This application became possible thanks to methods initially developed to facilitate the work of scientists.Peptides in themselves are not confusing, but the nomenclature used by the industry is. There is a mix of proprietary names, trade names, scientific names and INCI names, and they
are used in a confusing manner. To add to the confusion, the names have been changed in the INCI nomenclature from 2004 to 2008 (nobody knows why, except the people who changed the nomenclature but forgot to tell us why they did it).

In 1993 Katayana et al. found that a portion of procollagen fibrils stimulated the synthesis of procollagen and fibronectin. They continued to study that piece of procollagen until they found the minimum sequence required to get the stimulatory effect, a pentapeptide of sequence KTTKS, or Lys-Thr-Thr-Lys-Ser, or (using the full names of the amino acids) lysine-threonine-threonine-lysine-serine. The cosmetic industry took advantage of this discovery, marketing a modified pentapeptide. Matrixyl is an aqueous solution of palmitoyl pentapeptide-4 (INCI name), a.k.a. Pal-KTTKS.
Another synthetic peptide that copies a useful natural peptide is the copper peptide, a tripeptide (three amino acids linked in a short chain) of sequence GHK (glycine-hystidine-lysine) that carries copper in our plasma, and has been shown to accelerate wound healing.
 
Conversely, palmitoyl tetrapeptide-3 is an example of synthetic peptides that do NOT copy natural ones. The sequence of the peptide portion is GQPR (glycine-glutamine-proline-arginine). The marketing of this peptide says that it "helps skin appear younger by reducing the basal and UV-induced secretions of interleukin-6 in the keratinocytes and fibroblasts". There is no
way of checking this information anywhere, because whatever information they obtained it was not published in independent scientific journals. Because of the ubiquity of this peptide we decided to offer it in a mix that improves on Matrixyl 3000, which at present is a mix of palmitoyl
tetrapeptide-3 and GHQ peptide without the copper. With us, you do get the copper (rather than hoping that the peptide will find some copper on its way).

Palmitoyl tetrapeptide-3 and GHK-copper peptide. To achieve the perfect concentration and protect the peptide structure, the active is shipped to you in a solution containing distilled water, glycerol and preservatives. Please keep refrigerated until added to the cream.

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