The saikosaponins in Bupleurum Falcatum are mainly responsible for the plant's medicinal activities, but the pectins in this root extract also have immune system modulation activity. In vitro studies indicate saikosaponins have antiinflammatory effects by inhibiting arachidonic acid metabolism. Saikosaponin-d has immunoregulatory activity by promoting interleukin-2 production and receptor expression as well as modulating T-lymphocyte function.

Line Active ingredient in Lipocare™

Bupleurum is a good example of an active that we have been using for one purpose but our clients remind us that there are other uses for it. For our clients that are not interested in cellulite but have eczema problems, Bupleurum is an active to remember. Bupleurum falcatum root extract. Anti-cellulite, anti-inflammatory, anti-histaminic. The saikosaponins in Bupleurum falcatum are mainly responsible for the plant's medicinal activities, but the pectins in this root extract also have immune system modulation activity. In vitro studies indicate saikosaponins have antiinflammatory effects by inhibiting arachidonic acid metabolism. Saikosaponin-d has immunoregulatory activity by promoting interleukin-2 production and receptor expression as well as modulating T-lymphocyte function.

Each tube is enough for about 4 fl oz of cream or lotion at approximately 1% concentration (1 g in 120 mL cream). The powder will not dissolve immediately but will release components slowly into the cream or lotion, and can be combined with our other actives. Use in your favorite cream or add to our Canvas Base Cream, European Cream or our Sea Kelp Ultramarine.

Leung, Chung Yee; Liu, Liang; Wong, Ricky N. S.; Zeng, Yao Ying; Li, Ming; Zhou, Hua. (2005) Saikosaponin-d inhibits T cell activation through the modulation of PKC theta , JNK, and NF- kappaB transcription factor. Biochemical and Biophysical Research Communications, 338:1920-1927. Matsumoto, Tsukasa; Hosono-Nishiyama, Kanako; Guo, Ying-Jie; Ikejima, Takashi; Yamada, Haruki. (2005) A possible signal transduction pathway for cyclin D2 expression by a pectic polysaccharide from the roots of Bupleurum falcatum L. in murine B cell. International Immunopharmacology,5:1373-1386. Kato, Masashi; Pu, Mei-Yi; Isobe, Ken-Ichi; Iwamoto, Takashi; Nagase, Fumihiko; Lwin, Tint; Zhang, Yue-Hua; Hattori, Taku; Yanagita, Noriyuki; Nakashima, Izumi. (1994) Characterization of the immunoregulatory action of saikosaponin-d. Cellular Immunology 159:15-25. Park, Kwan Ha; Park, Jongmin; Koh, Dongsoo; Lim, Yoongho. (2002) Effect of Saikosaponin A, a triterpenoid glycoside, isolated from Bupleurum falcatum on experimental allergic asthma. Phytotherapy Research, 16: 359-363. Matsumoto, Tsukasa; Yamada, Haruki. (1995) Regulation of immune complexes binding of macrophages by pectic polysaccharide from Bupleurum falcatum L.: pharmacological evidence for the requirement of intracellular calcium/calmodulin on Fc receptor up-regulation by bupleuran 2IIb. Journal of Pharmacy and Pharmacology 47:152-6.

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Cellulite Control Cream

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