Acne control kit updated with Ultramarine sea kelp bioferment, nobiletin, oleuropein and granulysin

Acne is a serious matter, especially for the child/teen that has to live with it on top of all the other changes that adolescence brings. I don’t think that controlling acne will solve your teen’s problems (nothing can do that), but it will help. As a mother of a former teen who struggled with this problem, I know that I was ready to do use any medication in order to improve my child’s life. Now, through Skin Actives, we can provide a kit that should help the acne sufferer without long-term damage to the skin.

New: ZITender is an emergency gel, a must-have product for teens and young people battling acne.

Acne is a “perfect storm” in which abundant sebum production and imperfect shedding of dead cells lead to the formation of a “plug” that makes the closed pore a great feeding ground for a bacterium that doesn’t like oxygen, Propionibacterium acnes. Inflammation and mess follow. Cysts can develop when the contents of the sick follicle (keratinocytes, sebum and bacteria) spills into the surrounding dermis, producing a superficial pustule, or a deeper papule or nodule.

In my opinion, the problem with most acne products is that they only address one or two of the causes of acne, and then you need to use a “cannon” like benzoyl peroxide or antibiotics to keep the whole process under control. Although an antibiotic used at the right time on the right affliction can be a life saver, long term use of antibiotics is a bad idea. The same is true for benzoyl peroxide, which will also cause undesirable, long term changes in the skin.

As for other skin problems, the SAS approach is to address all the causes of acne simultaneously. Using this strategy, acne can be kept under control using lower concentrations of milder actives, and stress to the skin is kept to a minimum. The actives have different mechanisms of action, and “cannons” like benzoyl peroxide, antibiotics, steroids and alcohol are avoided.

What are the objectives?

1. Slow down conversion to the form of testosterone (male hormone) that binds to the androgen receptor in the skin
2. Control sebum synthesis and secretion
3. Normalize keratinization, preventing the exfoliated keratinocytes from sticking together and closing the pore
4. Decrease inflammation
5. Kill acne bacteria without decimating the normal bacterial flora of the skin.

Nobiletin (3',4',5,6,7,8-hexamethoxyflavone) inhibits synthesis of the type of fats (triglycerides) that is food for the acne bacterium and slows down proliferation of fat cells. It also has antibacterial activity. I think that in the near future you will hear a lot more about nobiletin, which also seems to have anti-aging and anti-tumor activity. Note: many thanks to the client who brought nobiletin to my attention.

Oleuropein is a chemical extracted from the olive tree (Olea Europea) that has anti-inflammatory activity; it also inhibits arachidonic acid-induced edema, and is an antioxidant.

Granulysin is an antibacterial protease that will increase penetration of the other ZITender actives.

Beta glucan enhances the immune response. The stimulating effect of these carbohydrates is not acquired through encounters with pathogens the way we acquire immunity to most microorganisms, but is innate, i.e. present in our genetic make-up. When we come in contact with beta glucans, our immune system seems to activate so that, when we come in contact with a pathogen, we are better able to deal with it and stop an infection.

Ultramarine seakelp bioferment: adds Porphyridium and Arthrospira extracts, and fucoidan (for more information please see July newsletter), to the great sea kelp bioferment, increasing the antioxidant and anti-inflammatory power of sea kelp.

Apply Acne Control cream nightly on clean, dry skin.

Rigano, L.; Cucchiara, M.(2003) Azeloyl-glycine: a new active in skin disequilibrium. Journal of Applied Cosmetology, 21:177-188. Fujimura T; Tsukahara K.; Moriwaki S.; Kitahara T.; Sano T.; Takema Y. (2002) Treatment of human skin with an extract of Fucus vesiculosus changes its thickness and mechanical properties J Cosmet Sci, 53(1), 1-9. Tanno, O.; Ota, Y.; Mitamura, N.; Inoue, S. (1997) Effects of niacinamide on ceramide biosynthesis and differentiation of cultured human keratinocytes. Scientific Conference of the Asian Societies of Cosmetic Scientists, 3rd, Taipei, May 23-24, 1997, 170-176 Johann, S., de OliveiraV.L., Pizzolatti, M.G., Schripsema, J. Braz-Filho, R. Branco, A., Smânia A. Jr (2007) Antimicrobial activity of wax and hexane extracts from Citrus spp. peels. Memorias Instituto Oswaldo Cruz: 102: 681-685 Sato T, Takahashi A, Kojima M, Akimoto N., Masamichi Y., and Ito, A. (2007) A citrus polymethoxy flavonoid, nobiletin inhibits sebum production and sebocyte proliferation, and augments sebum excretion in hamsters. J. Inv. Dermatology, 127: 2740-2748 Tanaka S, Sato T, Akimoto N, Yano M, Ito A (2004) Prevention of UVB-induced photoinflammation and photoaging by a polymethoxy flavonoid, nobiletin, in human keratinocytes in vivo and in vitro Biochemical Pharmacology 68: 433-439 Kollár, R, Reinhold B.B., Petráková, E. , Yeh, H.J.C., Ashwell, G., Drgonová, J., Kapteyn, J.C., Klis, F.M. and Cabib, Enrico (1997) Architecture of the Yeast Cell wall beta (1-->6)-glucan interconnects mannoprotein, beta (1-->3)-glucan, and chitin. Journal Biological Chemistry: 272: 17762-17775. Kougias, Panagiotis; Wei, Duo; Rice, Peter J.; Ensley, Harry E.; Kalbfleisch, John; Williams, David L.; Browder, I. William (2001) Normal human fibroblasts express pattern recognition receptors for fungal (1-->3)-beta-D-glucans. Infection and Immunity: 69: 3933-3938. Brown, Gordon D.; Gordon, Siamon (2001) Immune recognition: A new receptor for beta-glucans. Nature (London, United Kingdom) 413: 36-37.

Water, jojoba (Simmondsia chinensis) seed oil, Lactobacillus/kelp ferment filtrate, Porphyridium extract,  Laminaria japonica extract, Arthrospira extract., sorbitol, butylene glycol, cetyl alcohol, glyceryl stearate, saw palmetto (Serenoa repens) extract, niacinamide, PEG-100 Stearate, white willow (Salix alba) bark extract, stearyl alcohol, liquorice (Glycyrrhiza glabra) extract, EGCG from green tea (Camellia sinensis), wild yam (Dioscorea villosa) extract, yeast (Saccharomyces cerevisiae) beta glucan, sesame (Sesamum indicum) seed oil, sweet almond (Prunus amygdalus dulcis) oil, avocado (Persea gratissima) oil, nobiletin, retinyl acetate, oleuropein, sodium hyaluronate, polysorbate 20, citric acid, dimethicone, carbomer, triethanolamine, diazolidinyl urea, phenoxyethanol, methylparaben, propylparaben.

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Acne Control Set	T-Zone Serum	Salicylic Wash	Zit Ender
$47.50	$12.50	$12.50	$17.50
Beta Glucan (from Yeast)	Fucoidan (Brown Alga - Phaeophyta)	Green Tea Extract with EGCG	Licorice Extract
$7.50	$10.50	$10.50	$9.50
Niacinamide (Vitamin B3)	Nobiletin	Retinyl Acetate (Vitamin A)	Saw Palmetto
$8.50	$14.50	$4.50	$8.50
Sea Kelp Ultramarine	Wild Yam Diosgenin	Willow Bark Extract (Salicylic Acid)	Acne Control Mask
$15.50	$9.50	$5.50	$17.50

Betulinic Acid	Celestite Spritz with Strontium	Glucosamine (N-Acetyl)	Kit: Lip Health Customization
$13.50	$15.50	$3.50	$3.00
M and A Booster Cream	Olive Extract in Squalane	Scale	Serum Quartet Set
$18.50	$31.50	$15.00	$45.00
Ultramarine Nutrient Serum
$9.75

Product rating

Customer Reviews

• Author: Kelley
  I have always had a problem with very oily skin and almost constant breakouts. I have tried different products, and only benzoyl peroxide seemed to clear up my skin. But it also dried it out.
  
  I tried the Skin Actives acne kit and my skin has cleared up. It's remarkable. I have had one zit since using it and it cleared up in half the normal time. And my skin feels and looks so much healthier.
• Author: Vandana
  The T-Zone Serum is the best product I've ever used for my persistant acne. I'm 40 years old and I've struggled with acne all my life and continue to do so. I've tried everything and this is the best product to control/prevent my breakouts.
• Author: Tara
  This kit comes with quite a bit of cream (good value!), so I've also been using it as a skin cleanser as well. It works great and isn't harsh on inflamed skin. I mix up the T-Zone Serum with some of the collagen serum because Hannah advised that the collagen serum would help in lightening my acne marks.
  
  My only wish is that the kit be expanded to include a toner (maybe with some vitamin C and salicylic acid) and a day cream (preferably with a sunscreen) to protect from acne.
• Author: Marlena
  I only tried Zitender and it's wonderful. The best acne product. The face monsters disappear within 2 nights, and even after 1 night they shrink significantly! Pores are smaller and all inflammation are calming down. The only thing I'm not fond is the container, it is hard to use whole amount of the product, so please change that for a jar or softer tube!
• Author: Erin
  Just received my products yesterday and with one night of use I can totally see and feel a difference in my skin. Absolutely LOVE these products!!!!
• Author: Marites
  T-zone works very well for my pimples.
• Author: Stephanie
  This stuff is AMAZING! I have had many issues lately with my skin, it has gotten so bad that my doctor even switched my birth control pills to try and help my skin. But one day of using this set and I can already SEE and FEEL a difference. I will for sure keep stock in this.
• Author: Susan
  Having combatted acne since the estrogen kicked in, and having tried everything from glycolic / salicylic / benzoyl peroxide /applying ice packs / retin A, etc etc etc - I'm so happy to have found your T-Zone serum. I apply it morning and night on my 0-zone (it's hairline, forehead and chin for me) and it simply works. I can even apply creams on my face now, as long as I've applied this serum first.
• Author: Cass
  After using the Acne Control Cream for a number of months (along with all the other acne control products in the SAS line), I had to discontinue use because the products seemed to clog my pores/cause blackheads. The products seemed to work for the acne, I just didn't like the final results (the blackheads).